Four prescription weight-loss drugs are approved by the U.S. Food and Drug Administration (FDA) for long-term use: bupropion-naltrexone (Contrave), liraglutide (Saxenda), orlistat (Xenical) and phentermine-topiramate (Qsymia). Most prescription weight-loss drugs work by decreasing appetite or increasing feelings of fullness, and some do both.
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